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Article

Long-isoform NFE2L1 silencing inhibits acquisition of malignant phenotypes induced by arsenite in human bronchial epithelial cells.

Ecotoxicology and environmental safety - 1 Mar 2022

Li Yongfang, Sun Ru, Fang Xin, Ruan Yihui, Hu Yuxin, Wang Kemu, Liu Jiao, Wang Huihui, Pi Jingbo, Chen Yanyan, Xu Yuanyuan

Abstract excerpt

Chronic arsenic exposure is associated with the increased risk of several types of cancer, among which, lung cancer is the most deadly one. Nuclear factor erythroid 2 like 1 (NFE2L1), a transcription factor belonging to CNC-bZIP family, regulates multiple important cellular functions in response to acute arsenite exposure. However, the role of NFE2L1 in lung cancer induced by chronic arsenite exposure is unknown....

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PMID: 35124418
DOI: 10.1016/j.ecoenv.2022.113268

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