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Article

The aryl hydrocarbon receptor repressor is a putative tumor suppressor gene in multiple human cancers

2 Jan 2008

Abstract excerpt

The aryl hydrocarbon receptor repressor (AHRR) is a bHLH/Per-ARNT-Sim transcription factor located in a region of chromosome 5 (5p15.3) that has been proposed to contain one or more tumor suppressor genes. We report here consistent downregulation of AHRR mRNA in human malignant tissue from different anatomical origins, including colon, breast, lung, stomach, cervix, and ovary, and demonstrate DNA hypermethylation...

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Identifiers

PMID: 18172554
DOI: 10.1172/jci30024

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