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Article

Mutation of genes of the PI3K/AKT pathway in breast cancer supports their potential importance as biomarker for breast cancer aggressiveness.

Virchows Archiv : an international journal of pathology - 1 Jul 2016

Tserga Aggeliki, Chatziandreou Ilenia, Michalopoulos Nicolaos V, Patsouris Efstratios, Saetta Angelica A

Abstract excerpt

Deregulation of phosphatidylinositol 3-kinase (PI3K)/AKT signaling pathway is closely associated with cancer development and cancer progression. PIK3CA, AKT1, and PTEN are the fundamental molecules of the PI3K/AKT pathway with increased mutation rates in cancer cases leading to aberrant regulation of the pathway. Even though molecular alterations of the PI3K/AKT pathway have been studied in breast cancer,...

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Source

Identifiers

PMID: 27059323
DOI: 10.1007/s00428-016-1938-5

Genes

AKT1
AKT2
PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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