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Article

Correlation between activation of PI3K/AKT/mTOR pathway and prognosis of breast cancer in Chinese women.

PloS one - 1 Jan 2015

Deng Ling, Chen Jie, Zhong Xiao Rong, Luo Ting, Wang Yan Ping, Huang Hui Fen, Yin Li-Juan, Qiu Yan, Bu Hong, Lv Qing, Zheng Hong

Abstract excerpt

BACKGROUND: Abnormal activation of PI3K/AKT/mTOR (PAM) pathway, caused by PIK3CA mutation, KRAS mutation, PTEN loss, or AKT1 mutation, is one of the most frequent signaling abnormalities in breast carcinoma. However, distribution and frequencies of mutations in PAM pathway are unclear in breast cancer patients from the mainland of China and the correlation between these mutations and breast cancer outcome remains...

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Topics

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Share to Carcinoma, Ductal, Breast
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Proto-Oncogene Proteins c-akt

Share to TOR Serine-Threonine Kinases

Source

Open in PubMed Open full text

Identifiers

PMID: 25816324
DOI: 10.1371/journal.pone.0120511
PMCID: PMC4376391

Genes

PTEN
AKT1
KRAS
PAM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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