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Association of MITF and other melanosome-related proteins with chemoresistance in melanoma tumors and cell lines

6 Aug 2013

Abstract excerpt

Previous studies in cell lines have suggested a role for melanosomes and related protein trafficking pathways in melanoma drug response. We have investigated the expression of six proteins related to melanosomes and melanogenesis (MITF, GPR143, gp100/PMEL, MLANA, TYRP1, and RAB27A) in pretreatment metastases from melanoma patients (n = 52) with different response to dacarbazine/temozolomide....

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PMID: 23921446
DOI: 10.1097/cmr.0b013e328362f9cd

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