Biophysical characterization of melanoma cell phenotype markers during metastatic progression.

Abstract excerpt

Melanoma is the most fatal form of skin cancer, with increasing prevalence worldwide. The most common melanoma genetic driver is mutation of the proto-oncogene serine/threonine kinase BRAF; thus, the inhibition of its MAP kinase pathway by specific inhibitors is a commonly applied therapy. However, many patients are resistant, or develop resistance to this type of monotherapy, and therefore combined therapies...

Topics

Join the communities discussing this publication.

• Cell Line, Tumor
• Drug Resistance, Neoplasm
• Melanoma
• Mutation
• Phenotype