Article
MCU controls melanoma progression through a redox-controlled phenotype switch.
EMBO reports - 7 Nov 2022
Stejerean-Todoran Ioana, Zimmermann Katharina, Gibhardt Christine S, Vultur Adina, Ickes Christian, Shannan Batool, Bonilla Del Rio Zuriñe, Wölling Anna, Cappello Sabrina, Sung Hsu-Min, Shumanska Magdalena, Zhang Xin, Nanadikar Maithily, Latif Muhammad U, Wittek Anna, Lange Felix, Waters Andrea, Brafford Patricia, Wilting Jörg, Urlaub Henning, Katschinski Dörthe M, Rehling Peter, Lenz Christof, Jakobs Stefan, Ellenrieder Volker, Roesch Alexander, Schön Michael P, Herlyn Meenhard, Stanisz Hedwig, Bogeski Ivan
Abstract excerpt
Melanoma is the deadliest of skin cancers and has a high tendency to metastasize to distant organs. Calcium and metabolic signals contribute to melanoma invasiveness; however, the underlying molecular details are elusive. The MCU complex is a major route for calcium into the mitochondrial matrix but whether MCU affects melanoma pathobiology was not understood. Here, we show that MCUA expression correlates with...
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