Article

Melanin enhances metastatic melanoma colonization by inhibiting ferroptosis

2023-04-05

Abstract excerpt

Melanoma associated death is mainly caused by metastatic disease. Increased melanin levels are associated with decreased melanoma patient survival, yet the contribution of melanin to this process is unknown. Here we show that melanin protects circulating melanoma cells from ferroptosis, enhancing their metastatic potential. We observed that melanin levels in patient-derived uveal melanoma cells as well as cutaneou...

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Literature Corpus work: a2098951-9795-55cb-b824-cd084dc27cf2
DOI: 10.1101/2023.04.03.535376

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