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Article

Targeting protein-trafficking pathways alters melanoma treatment sensitivity.

Proceedings of the National Academy of Sciences of the United States of America - 10 Jan 2012

Huang Zhi-ming, Chinen Milka, Chang Philip J, Xie Tong, Zhong Lily, Demetriou Stephanie, Patel Mira P, Scherzer Rebecca, Sviderskaya Elena V, Bennett Dorothy C, Millhauser Glenn L, Oh Dennis H, Cleaver James E, Wei Maria L

Abstract excerpt

Protein-trafficking pathways are targeted here in human melanoma cells using methods independent of oncogene mutational status, and the ability to up-regulate and down-regulate tumor treatment sensitivity is demonstrated. Sensitivity of melanoma cells to cis-diaminedichloroplatinum II (cDDP, cis-platin), carboplatin, dacarbazine, or temozolomide together with velaparib, an inhibitor of poly (ADP ribose)...

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Identifiers

PMID: 22203954
DOI: 10.1073/pnas.1118366109
PMCID: PMC3258646

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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