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Article

Template-dependent nucleotide addition in the reverse (3'-5') direction by Thg1-like protein.

Science advances - 1 Mar 2016

Kimura Shoko, Suzuki Tateki, Chen Meirong, Kato Koji, Yu Jian, Nakamura Akiyoshi, Tanaka Isao, Yao Min

Abstract excerpt

Thg1-like protein (TLP) catalyzes the addition of a nucleotide to the 5'-end of truncated transfer RNA (tRNA) species in a Watson-Crick template-dependent manner. The reaction proceeds in two steps: the activation of the 5'-end by adenosine 5'-triphosphate (ATP)/guanosine 5'-triphosphate (GTP), followed by nucleotide addition. Structural analyses of the TLP and its reaction intermediates have revealed the atomic...

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Identifiers

PMID: 27051866
DOI: 10.1126/sciadv.1501397
PMCID: PMC4820378

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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