Article
Translocation and rotation of tRNA during template-independent RNA polymerization by tRNA nucleotidyltransferase.
Structure (London, England : 1993) - 4 Feb 2014
Yamashita Seisuke, Takeshita Daijiro, Tomita Kozo
Abstract excerpt
The 3'-terminal CCA (CCA-3' at positions 74-76) of tRNA is synthesized by CCA-adding enzyme using CTP and ATP as substrates, without a nucleic acid template. In Aquifex aeolicus, CC-adding and A-adding enzymes collaboratively synthesize the CCA-3'. The mechanism of CCA-3' synthesis by these two enzymes remained obscure. We now present crystal structures representing CC addition onto tRNA by A. aeolicus CC-adding...
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