Article
Evolution of eukaryal tRNA-guanine transglycosylase: insight gained from the heterocyclic substrate recognition by the wild-type and mutant human and Escherichia coli tRNA-guanine transglycosylases.
Nucleic acids research - 1 Apr 2011
Chen Yi-Chen, Brooks Allen F, Goodenough-Lashua DeeAnne M, Kittendorf Jeffrey D, Showalter Hollis D, Garcia George A
Abstract excerpt
The enzyme tRNA-guanine transglycosylase (TGT) is involved in the queuosine modification of tRNAs in eukarya and eubacteria and in the archaeosine modification of tRNAs in archaea. However, the different classes of TGTs utilize different heterocyclic substrates (and tRNA in the case of archaea). Based on the X-ray structural analyses, an earlier study [Stengl et al. (2005) Mechanism and substrate specificity of...
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