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Article

Crystallographic and mutational studies on the tRNA thiouridine synthetase TtuA.

Proteins - 1 Jul 2013

Nakagawa Hirofumi, Kuratani Mitsuo, Goto-Ito Sakurako, Ito Takuhiro, Katsura Kazushige, Terada Takaho, Shirouzu Mikako, Sekine Shun-Ichi, Shigi Naoki, Yokoyama Shigeyuki

Abstract excerpt

In thermophilic bacteria, specific 2-thiolation occurs on the conserved ribothymidine at position 54 (T54) in tRNAs, which is necessary for survival at high temperatures. T54 2-thiolation is achieved by the tRNA thiouridine synthetase TtuA and sulfur-carrier proteins. TtuA has five conserved CXXC/H motifs and the signature PP motif, and belongs to the TtcA family of tRNA 2-thiolation enzymes, for which there is...

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PMID: 23444054
DOI: 10.1002/prot.24273

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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