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Article

The RNA-binding PUA domain of archaeal tRNA-guanine transglycosylase is not required for archaeosine formation.

The Journal of biological chemistry - 17 Mar 2006

Sabina Jeffrey, Söll Dieter

Abstract excerpt

Bacterial tRNA-guanine transglycosylase (TGT) replaces the G in position 34 of tRNA with preQ(1), the precursor to the modified nucleoside queuosine. Archaeal TGT, in contrast, substitutes preQ(0) for the G in position 15 of tRNA as the first step in archaeosine formation. The archaeal enzyme is about 60% larger than the bacterial protein; a carboxyl-terminal extension of 230 amino acids contains the PUA domain...

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PMID: 16407303
DOI: 10.1074/jbc.M512841200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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