Article
Structural basis for recognition of G-1-containing tRNA by histidyl-tRNA synthetase.
Nucleic acids research - 11 Mar 2015
Tian Qingnan, Wang Caiyan, Liu Yuhuan, Xie Wei
Abstract excerpt
Aminoacyl-tRNA synthetases (aaRSs) play a crucial role in protein translation by linking tRNAs with cognate amino acids. Among all the tRNAs, only tRNA(His) bears a guanine base at position -1 (G-1), and it serves as a major recognition element for histidyl-tRNA synthetase (HisRS). Despite strong interests in the histidylation mechanism, the tRNA recognition and aminoacylation details are not fully understood. We...
Topics
- Amino Acid Sequence
- Aminoacylation
- Base Sequence
- Catalytic Domain
- Crystallography, X-Ray
- Guanine
- Histidine-tRNA Ligase
- Models, Molecular
- Molecular Sequence Data
- Mutation
- Nucleic Acid Conformation