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Article

Minimal requirements for reverse polymerization and tRNA repair by tRNAHis guanylyltransferase.

RNA biology - 1 Jan 2018

Desai Riddhi, Kim Kunmo, Büchsenschütz Hanna C, Chen Allan W, Bi Yumin, Mann Mitchell R, Turk Matthew A, Chung Christina Z, Heinemann Ilka U

Abstract excerpt

tRNAHis guanylyltransferase (Thg1) has unique reverse (3'-5') polymerase activity occurring in all three domains of life. Most eukaryotic Thg1 homologs are essential genes involved in tRNAHis maturation. These enzymes normally catalyze a single 5' guanylation of tRNAHis lacking the essential G-1 identity element required for aminoacylation. Recent studies suggest that archaeal type Thg1, which includes most...

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Identifiers

PMID: 28901837
DOI: 10.1080/15476286.2017.1372076
PMCID: PMC6103667

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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