APE1 polymorphic variants cause persistent genomic stress and affect cancer cell proliferation.

doi:10.18632/oncotarget.8477

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Article

APE1 polymorphic variants cause persistent genomic stress and affect cancer cell proliferation.

Oncotarget - 3 May 2016

Lirussi Lisa, Antoniali Giulia, D'Ambrosio Chiara, Scaloni Andrea, Nilsen Hilde, Tell Gianluca

Abstract excerpt

Apurinic/apyrimidinic endonuclease 1 (APE1) is the main mammalian AP-endonuclease responsible for the repair of endogenous DNA damage through the base excision repair (BER) pathway. Molecular epidemiological studies have identified several genetic variants associated with human diseases, but a well-defined functional connection between mutations in APE1 and disease development is lacking. In order to understand...

Topics

Cell Proliferation
DNA Repair
DNA-(Apurinic or Apyrimidinic Site) Lyase
Genetic Predisposition to Disease
Genotype
HeLa Cells
Humans
Neoplasms
Polymorphism, Single Nucleotide

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Identifiers

PMID: 27050370
DOI: 10.18632/oncotarget.8477
PMCID: PMC5041981

Genes

XRCC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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