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Article

Functional assessment of population and tumor-associated APE1 protein variants.

PloS one - 1 Jan 2013

Illuzzi Jennifer L, Harris Nicole A, Manvilla Brittney A, Kim Daemyung, Li Mengxia, Drohat Alexander C, Wilson David M

Abstract excerpt

Apurinic/apyrimidinic endonuclease 1 (APE1) is the predominant AP site repair enzyme in mammals. APE1 also maintains 3'-5' exonuclease and 3'-repair activities, and regulates transcription factor DNA binding through its REF-1 function. Since complete or severe APE1 deficiency leads to embryonic lethality and cell death, it has been hypothesized that APE1 protein variants with slightly impaired function will...

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Share to Amino Acid Substitution
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 23776569
DOI: 10.1371/journal.pone.0065922
PMCID: PMC3679070

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