Article
Genetic polymorphisms in APE1 Asp148Glu(rs3136820) as a modifier of the background levels of abasic sites in human leukocytes derived from breast cancer patients and controls.
Breast cancer (Tokyo, Japan) - 1 May 2017
Hsieh Wei-Chung, Lin Che, Chen Dar-Ren, Yu Wen-Fa, Chen Guan-Jie, Hu Suh-Woan, Liu Chin-Chen, Ge Mao-Huei, Ruan Chang-Sin, Chen Cheng-You, Lin Chia-Hua, Lin Po-Hsiung
Abstract excerpt
BACKGROUND: Apurinic/apyrimidinic (abasic/AP) sites are among the most common endogenous DNA lesions. AP sites, if not repaired, could result in genomic instability as well as chromosome aberrations. Information regarding the direct assay of the number of abasic sites in human leukocytes and its association with risk of breast cancer has not been reported. METHODS: In this study, we investigated the association...
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