Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Human Apurinic/Apyrimidinic Endonuclease (APE1) Is Acetylated at DNA Damage Sites in Chromatin, and Acetylation Modulates Its DNA Repair Activity

23 Dec 2016

Abstract excerpt

Apurinic/apyrimidinic (AP) sites, the most frequently formed DNA lesions in the genome, inhibit transcription and block replication. The primary enzyme that repairs AP sites in mammalian cells is the AP endonuclease (APE1), which functions through the base excision repair (BER) pathway. Although the mechanism by which APE1 repairs AP sites in vitro has been extensively investigated, it is largely unknown how APE1...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Advanced biosensing and bioanalysis techniques
Share to DNA Repair Mechanisms
Share to PARP inhibition in cancer therapy

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 27994014
DOI: 10.1128/mcb.00401-16

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Human Apurinic/Apyrimidinic Endonuclease (APE1) Is Acetylated at DNA Damage Sites in Chromatin, and Acetylation Modulates Its DNA Repair ActivityPMID 27994014Read ↗

Processing of oxidatively damaged DNA dirty ends by APE1Semantic proximity Read ↗

Human Apurinic/Apyrimidinic Endonuclease 1Semantic proximity Read ↗

SIRT1 gene expression upon genotoxic damage is regulated by APE1 through nCaRE-promoter elementsSemantic proximity Read ↗

A review on protein–protein interaction network of APE1/Ref‐1 and its associated biological functionsSemantic proximity Read ↗

APE1 polymorphic variants cause persistent genomic stress and affect cancer cell proliferation.Semantic proximity Read ↗

Molecular and structural characterization of disease-associated APE1 polymorphisms.Semantic proximity Read ↗

Essential role for mammalian apurinic/apyrimidinic (AP) endonuclease Ape1/Ref-1 in telomere maintenanceSemantic proximity Read ↗

Knockout and Inhibition of Ape1: Roles of Ape1 in Base Excision DNA Repair and Modulation of Gene ExpressionSemantic proximity Read ↗

The chromatin remodeler ERCC6 and the histone chaperone NAP1 are involved in apurinic/apyrimidinic endonuclease-mediated DNA repairSemantic proximity Read ↗

Functional Role of N-Terminal Extension of Human AP Endonuclease 1 In Coordination of Base Excision DNA Repair via Protein-Protein Interactions.Semantic proximity Read ↗

XRCC1 coordinates the initial and late stages of DNA abasic site repair through protein-protein interactions.Semantic proximity Read ↗

Genetic and biochemical characterization of human AP endonuclease 1 mutants deficient in nucleotide incision repair activity.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.