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Article

SIRT1 gene expression upon genotoxic damage is regulated by APE1 through nCaRE-promoter elements

20 Dec 2013

Abstract excerpt

Apurinic/apyrimidinic endonuclease 1 (APE1) is a multifunctional protein contributing to genome stability via repair of DNA lesions via the base excision repair pathway. It also plays a role in gene expression regulation and RNA metabolism. Another, poorly characterized function is its ability to bind to negative calcium responsive elements (nCaRE) of some gene promoters. The presence of many functional nCaRE...

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PMID: 24356447
DOI: 10.1091/mbc.e13-05-0286

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