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Article

Learning defects in Drosophila growth restricted chico mutants are caused by attenuated adenylyl cyclase activity.

Molecular brain - 6 Apr 2016

Naganos Shintaro, Ueno Kohei, Horiuchi Junjiro, Saitoe Minoru

Abstract excerpt

BACKGROUND: Reduced insulin/insulin-like growth factor signaling (IIS) is a major cause of symmetrical intrauterine growth retardation (IUGR), an impairment in cell proliferation during prenatal development that results in global growth defects and mental retardation. In Drosophila, chico encodes the only insulin receptor substrate. Similar to other animal models of IUGR, chico mutants have defects in global...

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PMID: 27048332
DOI: 10.1186/s13041-016-0217-3
PMCID: PMC4822261

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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