Article
Altered gene regulation and synaptic morphology in Drosophila learning and memory mutants.
Learning & memory (Cold Spring Harbor, N.Y.) - 1 Jan 2011
Guan Zhuo, Buhl Lauren K, Quinn William G, Littleton J Troy
Abstract excerpt
Genetic studies in Drosophila have revealed two separable long-term memory pathways defined as anesthesia-resistant memory (ARM) and long-lasting long-term memory (LLTM). ARM is disrupted in radish (rsh) mutants, whereas LLTM requires CREB-dependent protein synthesis. Although the downstream effectors of ARM and LLTM are distinct, pathways leading to these forms of memory may share the cAMP cascade critical for...
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