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Article

Mutations in the Drosophila insulin receptor substrate, CHICO, impair olfactory associative learning.

Neuroscience research - 1 May 2012

Naganos Shintaro, Horiuchi Junjiro, Saitoe Minoru

Abstract excerpt

CHICO, the Drosophila homolog of vertebrate insulin receptor substrate (IRS), mediates insulin/insulin-like growth factor signaling (IIS), and reductions in chico severely disrupt cell growth and proliferation. We found extensive expression of chico in various Drosophila brain regions including the mushroom bodies (MBs), critical neural structures for olfactory learning. chico null mutants have significantly...

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PMID: 22342328
DOI: 10.1016/j.neures.2012.02.001

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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