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Article

CASY-1, an ortholog of calsyntenins/alcadeins, is essential for learning in Caenorhabditis elegans.

Proceedings of the National Academy of Sciences of the United States of America - 1 Apr 2008

Ikeda Daisuke D, Duan Yukan, Matsuki Masahiro, Kunitomo Hirofumi, Hutter Harald, Hedgecock Edward M, Iino Yuichi

Abstract excerpt

Calsyntenins/alcadeins are type I transmembrane proteins with two extracellular cadherin domains highly expressed in mammalian brain. They form a tripartite complex with X11/X11L and APP (amyloid precursor protein) and are proteolytically processed in a similar fashion to APP. Although a genetic association of calsyntenin-2 with human memory performance has recently been reported, physiological roles and...

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Identifiers

PMID: 18381821
DOI: 10.1073/pnas.0711894105
PMCID: PMC2278220

Genes

APP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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