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Article

Adult single-nucleus neuronal transcriptomes of insulin signaling mutants reveal regulators of behavior and learning.

Cell genomics - 11 Dec 2024

St Ange Jonathan, Weng Yifei, Kaletsky Rachel, Stevenson Morgan E, Moore Rebecca S, Zhou Shiyi, Murphy Coleen T

Abstract excerpt

Gene expression in individual neurons can change during development to adulthood and can have large effects on behavior. Additionally, the insulin/insulin-like signaling (IIS) pathway regulates many of the adult functions of Caenorhabditis elegans, including learning and memory, via transcriptional changes. We used the deep resolution of single-nucleus RNA sequencing to define the adult transcriptome of each...

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PMID: 39637862
DOI: 10.1016/j.xgen.2024.100720
PMCID: PMC11701262

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