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Article

Dystrophin-deficient dogs with reduced myostatin have unequal muscle growth and greater joint contractures.

Skeletal muscle - 1 Jan 2016

Kornegay Joe N, Bogan Daniel J, Bogan Janet R, Dow Jennifer L, Wang Jiahui, Fan Zheng, Liu Naili, Warsing Leigh C, Grange Robert W, Ahn Mihye, Balog-Alvarez Cynthia J, Cotten Steven W, Willis Monte S, Brinkmeyer-Langford Candice, Zhu Hongtu, Palandra Joe, Morris Carl A, Styner Martin A, Wagner Kathryn R

Abstract excerpt

BACKGROUND: Myostatin (Mstn) is a negative regulator of muscle growth whose inhibition promotes muscle growth and regeneration. Dystrophin-deficient mdx mice in which myostatin is knocked out or inhibited postnatally have a less severe phenotype with greater total mass and strength and less fibrosis and fatty replacement of muscles than mdx mice with wild-type myostatin expression. Dogs with golden retriever...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 27047655
DOI: 10.1186/s13395-016-0085-7
PMCID: PMC4819282

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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