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Article

Age-dependent effect of myostatin blockade on disease severity in a murine model of limb-girdle muscular dystrophy.

The American journal of pathology - 1 Jun 2006

Parsons Stephanie A, Millay Douglas P, Sargent Michelle A, McNally Elizabeth M, Molkentin Jeffery D

Abstract excerpt

Myostatin (MSTN) is a muscle-specific secreted peptide that functions to limit muscle growth through an autocrine regulatory feedback loop. Loss of MSTN activity in cattle, mice, and humans leads to a profound phenotype of muscle overgrowth, associated with more and larger fibers and enhanced regenerative capacity. Deletion of MSTN in the mdx mouse model of Duchenne muscular dystrophy enhances muscle mass and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 16723712
DOI: 10.2353/ajpath.2006.051316
PMCID: PMC1606625

Genes

MSTN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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