Article
Sparing of the dystrophin-deficient cranial sartorius muscle is associated with classical and novel hypertrophy pathways in GRMD dogs.
The American journal of pathology - 1 Nov 2013
Nghiem Peter P, Hoffman Eric P, Mittal Priya, Brown Kristy J, Schatzberg Scott J, Ghimbovschi Svetlana, Wang Zuyi, Kornegay Joe N
Abstract excerpt
Both Duchenne and golden retriever muscular dystrophy (GRMD) are caused by dystrophin deficiency. The Duchenne muscular dystrophy sartorius muscle and orthologous GRMD cranial sartorius (CS) are relatively spared/hypertrophied. We completed hierarchical clustering studies to define molecular mechanisms contributing to this differential involvement and their role in the GRMD phenotype. GRMD dogs with larger CS...
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