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Article

Evaluating the impact of missenses mutations in CYP2D67 and CYP2D614A: does it compromise tamoxifen metabolism?

Pharmacogenomics - 1 Apr 2016

Borba Maria Acsm, Melo-Neto Renato P, Leitão Glauber M, Castelletti Carlos Hm, Lima-Filho José L, Martins Danyelly Bg

Abstract excerpt

UNLABELLED: CYP2D6 is a high polymorphic enzyme from P450, responsible for metabolizing almost 25% of drugs. The distribution of different mutations among CYP2D6 alleles has been associated with poor, intermediate, extensive and ultra-metabolizers. AIM: To evaluate how missenses mutations in CYP2D6*7 and CYP2D6*14A poor metabolizer alleles affect CYP2D6 stability and function. MATERIALS & METHODS: CYPalleles...

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Source

Identifiers

PMID: 27043475
DOI: 10.2217/pgs-2015-0003

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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