Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Benchmarking analysis of deleterious SNP prediction tools on CYP2D6 enzyme.

Chemical biology & drug design - 1 Sept 2020

Ferreira Karla Cristina do Vale, Fialho Leonardo Ferreira, Franco Octávio Luiz, de Alencar Sérgio Amorim, Porto William Farias

Abstract excerpt

The cytochrome P450 family is composed of hemeproteins involved in the metabolic transformation of endogenous and exogenous substances. The CYP2D6 enzyme is responsible for the metabolism of ~25% of clinically used drugs and is mainly expressed in the liver. The CYP2D6 gene is known to have a large number of single nucleotide polymorphisms (SNPs). Nevertheless, these variations could modify the CYP2D6 enzyme's...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Algorithms
Share to Cytochrome P-450 CYP2D6

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mutation, Missense

Share to Polymorphism, Single Nucleotide

Source

Identifiers

PMID: 32149466
DOI: 10.1111/cbdd.13676

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Benchmarking analysis of deleterious SNP prediction tools on CYP2D6 enzyme.PMID 32149466Read ↗

Benchmarking analysis of deleterious SNP prediction tools on CYP2D6 enzymeSemantic proximity Read ↗

Identification of the effects of pathogenic genetic variations of human CYP2C9 and CYP2D6: an in silico approach.Semantic proximity Read ↗

A Review of the Important Role of CYP2D6 in Pharmacogenomics.Semantic proximity Read ↗

Pharmacogenomics: analysing SNPs in the CYP2D6 gene using amino acid properties.Semantic proximity Read ↗

Proof of principle concept for the analysis and functional prediction of rare genetic variants in the CYP2C19 and CYP2D6 genes.Semantic proximity Read ↗

Development and characterization of a rapid and comprehensive genotyping assay to detect the most common variants in cytochrome P450 2D6.Semantic proximity Read ↗

CYP-nsSNP: a specialized database focused on effect of non-synonymous SNPs on function of CYPs.Semantic proximity Read ↗

Evaluating the impact of missenses mutations in CYP2D6*7 and CYP2D6*14A: does it compromise tamoxifen metabolism?Semantic proximity Read ↗

Genetic variations of human CYP2D6 in the Chinese Han population.Semantic proximity Read ↗

Sequencing the CYP2D6 gene: from variant allele discovery to clinical pharmacogenetic testing.Semantic proximity Read ↗

PharmVar Tutorial on CYP2D6 Structural Variation Testing and Recommendations on Reporting.Semantic proximity Read ↗

Cyrius: accurate CYP2D6 genotyping using whole-genome sequencing data.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.