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Article

Characterizing the combined effects of cytochrome P450 missense variation within star allele definitions.

Pharmacogenomics - 1 Jul 2023

Khoza Nhlamulo, Twesigomwe David, Othman Houcemeddine

Abstract excerpt

Background: Cytochrome P450 (CYP) genetic variation largely impacts drug response. However, many CYP star alleles (haplotypes) lack functional annotation, impeding our understanding of drug metabolism mechanisms. We aimed to investigate the impact of missense variant combinations on CYP protein structures. Methods: Normal mode analysis was conducted on 261 missense variants within 91 CYP haplotypes. CYP2D6*2 and...

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Identifiers

PMID: 37503750
DOI: 10.2217/pgs-2023-0068

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