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Article

Pharmacogenomics: analysing SNPs in the CYP2D6 gene using amino acid properties.

International journal of bioinformatics research and applications - 1 Jan 2007

Ebbert Mark T W, Beckstead Wesley A, O'Connor Timothy D, Clement Mark J, McClellan David A

Abstract excerpt

The CYP2D6 gene is responsible for metabolising a large portion of the commonly prescribed drugs. Because of its importance, various approaches have been taken to analyse CYP2D6 and Single Nucleotide Polymorphisms (SNPs) throughout its sequence. This study introduces a novel method to analyse the effects of SNPs on encoded protein complexes by focusing on the biochemical properties of each non-synonymous...

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Identifiers

PMID: 18048313
DOI: 10.1504/IJBRA.2007.015415

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