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Article

c-Met–mediated endothelial plasticity drives aberrant vascularization and chemoresistance in glioblastoma

3 Apr 2016

Abstract excerpt

Aberrant vascularization is a hallmark of cancer progression and treatment resistance. Here, we have shown that endothelial cell (EC) plasticity drives aberrant vascularization and chemoresistance in glioblastoma multiforme (GBM). By utilizing human patient specimens, as well as allograft and genetic murine GBM models, we revealed that a robust endothelial plasticity in GBM allows acquisition of fibroblast...

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PMID: 27043280
DOI: 10.1172/jci84876

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