Article

Endothelial-secreted Endocan protein acts as a PDGFR alpha ligand and regulates vascularity, radioresistance, and regional phenotype in glioblastoma

2020-10-12

Abstract excerpt

One of the hallmarks of glioblastoma (GBM) is extensive neovascularization. In addition to supplying blood and nutrients, vascular endothelial (VE) cells provide trophic support to GBM cells via paracrine signaling, the precise mechanisms of which are being unraveled. Here, using patient-derived GBM and VE cells as well as orthotopic GBM mouse models, we report that Endocan ( ESM1 ), an endothelial-secreted prote...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 01748b56-0c8e-53f8-acb5-9eee6ab927c6
DOI: 10.1101/2020.10.12.335091

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Endothelial-secreted Endocan protein acts as a PDGFR alpha ligand and regulates vascularity, radioresistance, and regional phenotype in glioblastomaDOI 10.1101/2020.10.12.335091Read

Endothelial-secreted Endocan activates PDGFRA and regulates vascularity and spatial phenotype in glioblastoma.Semantic proximity Read

Identification of diverse tumor endothelial cell populations in malignant gliomaSemantic proximity Read

Understanding the Role of Endothelial Cells in Glioblastoma: Mechanisms and Novel TreatmentsSemantic proximity Read

c-Met–mediated endothelial plasticity drives aberrant vascularization and chemoresistance in glioblastomaSemantic proximity Read

Endocan as a Biomarker of Endothelial Dysfunction in CancerSemantic proximity Read

Tumor-Derived Pericytes Driven by EGFR Mutations Govern the Vascular and Immune Microenvironment of Gliomas.Semantic proximity Read

Pericytes orchestrate a tumor-restraining microenvironment in glioblastomaSemantic proximity Read

Pericyte–Glioblastoma Cell Interaction: A Key Target to Prevent Glioblastoma ProgressionSemantic proximity Read

Low- and high-grade glioma endothelial cells differentially regulate tumor growthSemantic proximity Read

Characteristics of tumor-associated endothelial cells derived from glioblastoma multiformeSemantic proximity Read

Human cortico-vascular assembloids reveal a CELF2-AHNAK-dependent switch from neuronal to endothelial tropism in glioblastoma cellsSemantic proximity Read

The glioblastoma vasculature as a target for cancer therapySemantic proximity Read