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Blood-brain barrier alterations in human brain tumors revealed by genome-wide transcriptomic profiling

4 Feb 2021

Abstract excerpt

BACKGROUND: Brain tumors, whether primary or secondary, have limited therapeutic options despite advances in understanding driver gene mutations and heterogeneity within tumor cells. The cellular and molecular composition of brain tumor stroma, an important modifier of tumor growth, has been less investigated to date. Only few studies have focused on the vasculature of human brain tumors despite the fact that the...

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PMID: 33560373
DOI: 10.1093/neuonc/noab022

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