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Article

MET Signaling Regulates Glioblastoma Stem Cells

23 May 2012

Abstract excerpt

Glioblastomas multiforme (GBM) contain highly tumorigenic, self-renewing populations of stem/initiating cells [glioblastoma stem cells (GSC)] that contribute to tumor propagation and treatment resistance. However, our knowledge of the specific signaling pathways that regulate GSCs is limited. The MET tyrosine kinase is known to stimulate the survival, proliferation, and invasion of various cancers including GBM....

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PMID: 22617325
DOI: 10.1158/0008-5472.can-11-3760

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