Article
Endothelial-secreted Endocan activates PDGFRA and regulates vascularity and spatial phenotype in glioblastoma.
Nature communications - 7 Jan 2025
Bastola Soniya, Pavlyukov Marat S, Sharma Neel, Ghochani Yasmin, Nakano Mayu A, Muthukrishnan Sree Deepthi, Yu Sang Yul, Kim Min Soo, Sohrabi Alireza, Biscola Natalia P, Yamashita Daisuke, Anufrieva Ksenia S, Kovalenko Tatyana F, Jung Grace, Ganz Tomas, O'Brien Beatrice, Kawaguchi Riki, Qin Yue, Seidlits Stephanie K, Burlingame Alma L, Oses-Prieto Juan A, Havton Leif A, Goldman Steven A, Hjelmeland Anita B, Nakano Ichiro, Kornblum Harley I
Abstract excerpt
Extensive neovascularization is a hallmark of glioblastoma (GBM). In addition to supplying oxygen and nutrients, vascular endothelial cells provide trophic support to GBM cells via paracrine signaling. Here we report that Endocan (ESM1), an endothelial-secreted proteoglycan, confers enhanced proliferative, migratory, and angiogenic properties to GBM cells and regulates their spatial identity. Mechanistically,...
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