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Article

Brinp1(-/-) mice exhibit autism-like behaviour, altered memory, hyperactivity and increased parvalbumin-positive cortical interneuron density.

Molecular autism - 1 Jan 2016

Berkowicz Susan R, Featherby Travis J, Qu Zhengdong, Giousoh Aminah, Borg Natalie A, Heng Julian I, Whisstock James C, Bird Phillip I

Abstract excerpt

BACKGROUND: BMP/RA-inducible neural-specific protein 1 (Brinp1) is highly conserved in vertebrates, and continuously expressed in the neocortex, hippocampus, olfactory bulb and cerebellum from mid-embryonic development through to adulthood. METHODS: Brinp1 knock-out (Brinp1(-/-)) mice were generated by Cre-recombinase-mediated removal of the third exon of Brinp1. Knock-out mice were characterised by behavioural...

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Identifiers

PMID: 27042284
DOI: 10.1186/s13229-016-0079-7
PMCID: PMC4818446

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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