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Article

Knockout of NMDA receptors in parvalbumin interneurons recreates autism-like phenotypes.

Autism research : official journal of the International Society for Autism Research - 1 Apr 2013

Saunders John A, Tatard-Leitman Valerie M, Suh Jimmy, Billingslea Eddie N, Roberts Timothy P, Siegel Steven J

Abstract excerpt

Autism is a disabling neurodevelopmental disorder characterized by social deficits, language impairment, and repetitive behaviors with few effective treatments. New evidence suggests that autism has reliable electrophysiological endophenotypes and that these measures may be caused by n-methyl-d-aspartic acid receptor (NMDAR) disruption on parvalbumin (PV)-containing interneurons. These findings could be used to...

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Identifiers

PMID: 23441094
DOI: 10.1002/aur.1264
PMCID: PMC4064157

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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