Article
Behavioral and Neuroanatomical Phenotypes in Mouse Models of Autism.
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics - 1 Jul 2015
Ellegood Jacob, Crawley Jacqueline N
Abstract excerpt
In order to understand the consequences of the mutation on behavioral and biological phenotypes relevant to autism, mutations in many of the risk genes for autism spectrum disorder have been experimentally generated in mice. Here, we summarize behavioral outcomes and neuroanatomical abnormalities, with a focus on high-resolution magnetic resonance imaging of postmortem mouse brains. Results are described from...
Topics
- Animals
- Autism Spectrum Disorder
- Behavior, Animal
- Brain
- Disease Models, Animal
- Genetic Predisposition to Disease
- Magnetic Resonance Imaging
- Mice
- Mice, Inbred BALB C
- Mice, Inbred C57BL
- Mutation
- Phenotype
- Reelin Protein
- Risk Factors
- Social Behavior