Article
Single nucleotide polymorphisms in candidate genes and dengue severity in children: a case-control, functional and meta-analysis study.
Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases - 1 Dec 2013
Xavier-Carvalho Caroline, Gibson Gerusa, Brasil Patrícia, Ferreira Ralph X, de Souza Santos Reinaldo, Gonçalves Cruz Oswaldo, de Oliveira Solange Artimos, de Sá Carvalho Marília, Pacheco Antonio G, Kubelka Claire F, Moraes Milton O
Abstract excerpt
Dengue is an arthropod-borne emerging viral disease with high morbidity and mortality risk in tropical countries like Brazil. Clinical manifestations are vast, ranging from asymptomatic to most severe forms of dengue such as shock. Previous data have shown that host genetics play a role in disease susceptibility and severity. Herein, we have tested the association of single nucleotide polymorphisms (SNPs) at TNF,...
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