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Article

Protein Aggregation and Defective RNA Metabolism as Mechanisms for Motor Neuron Damage

1 Jul 2010

Abstract excerpt

The presence of protein inclusions within the central nervous system is a characteristic of most neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS). Aggregates may induce cell death trough several mechanisms, such as sequestration of essential cellular components, clogging of the proteasome system, and/or disruption of axonal transport. The neuropathological signature of ALS is represented...

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PMID: 20406182
DOI: 10.2174/187152710791292585

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