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TDP‐43 and FUS/TLS: cellular functions and implications for neurodegeneration

21 Jul 2011

Abstract excerpt

TDP-43 (transactive response binding protein of 43 kDa) and FUS (fused in sarcoma) comprise the neuropathological protein aggregates of distinct subtypes of the neurodegenerative diseases frontotemporal lobar degeneration and amyotrophic lateral sclerosis. Moreover, the genes encoding TDP-43 and FUS are linked to these diseases. Both TDP-43 and FUS contain RNA binding motifs, and specific targets are being...

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PMID: 21777389
DOI: 10.1111/j.1742-4658.2011.08258.x

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