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Article

TDP-43 and FUS in amyotrophic lateral sclerosis and frontotemporal dementia.

The Lancet. Neurology - 1 Oct 2010

Mackenzie Ian Ra, Rademakers Rosa, Neumann Manuela

Abstract excerpt

Abnormal intracellular protein aggregates comprise a key characteristic in most neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). The seminal discoveries of accumulation of TDP-43 in most cases of ALS and the most frequent form of FTD, fr...

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Source

Identifiers

PMID: 20864052
DOI: 10.1016/S1474-4422(10)70195-2

Genes

FUS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20864052-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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