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Article

TDP-43 and FUS in amyotrophic lateral sclerosis and frontotemporal dementia.

The Lancet. Neurology - 1 Oct 2010

Mackenzie Ian Ra, Rademakers Rosa, Neumann Manuela

Abstract excerpt

Abnormal intracellular protein aggregates comprise a key characteristic in most neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). The seminal discoveries of accumulation of TDP-43 in most cases of ALS and the most frequent form of FTD, frontotemporal lobar degeneration with ubiquitinated inclusions, followed by identification of FUS as the novel...

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Source

Identifiers

PMID: 20864052
DOI: 10.1016/S1474-4422(10)70195-2

Genes

FUS

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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