Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Variation in the HFE gene is associated with the development of bleomycin-induced pulmonary toxicity in testicular cancer patients.

European journal of cancer (Oxford, England : 1990) - 1 May 2016

van der Schoot Gabriela G F, Westerink Nico-Derk L, Lubberts Sjoukje, Nuver Janine, Zwart Nynke, Walenkamp Annemiek M E, Wempe Johan B, Meijer Coby, Gietema Jourik A

Abstract excerpt

BACKGROUND: Bleomycin and cisplatin are of key importance in testicular cancer treatment. Known potential serious adverse effects are bleomycin-induced pulmonary toxicity (BIP) and cisplatin-induced renal toxicity. Iron handling may play a role in development of this toxicity. Carriage of allelic variants of the HFE gene induces altered iron metabolism and may contribute to toxicity. We investigated the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antineoplastic Combined Chemotherapy Protocols
Share to Bleomycin

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cisplatin

Share to Hemochromatosis Protein

Share to Iron Overload

Share to Kidney Diseases

Share to Lung Diseases

Share to Testicular Neoplasms

Source

Identifiers

PMID: 27033261
DOI: 10.1016/j.ejca.2016.02.013

Genes

HFE

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Variation in the HFE gene is associated with the development of bleomycin-induced pulmonary toxicity in testicular cancer patients.PMID 27033261Read ↗

Genetic variation in the bleomycin hydrolase gene and bleomycin-induced pulmonary toxicity in germ cell cancer patients.Semantic proximity Read ↗

HFE C282Y mutation as a genetic modifier influencing disease susceptibility for chronic myeloproliferative disease.Semantic proximity Read ↗

Impact of HFE variants and sex in lung cancer.Semantic proximity Read ↗

HFE C282Y and H63D in adults with malignancies in a community medical oncology practice.Semantic proximity Read ↗

Impact of hemochromatosis gene (HFE) mutations on epithelial ovarian cancer risk and prognosis.Semantic proximity Read ↗

Increased prevalence of the HFE C282Y hemochromatosis allele in women with breast cancer.Semantic proximity Read ↗

HFE gene mutations in susceptibility to childhood leukemia: HuGE review.Semantic proximity Read ↗

Variation in bleomycin hydrolase gene is associated with reduced survival after chemotherapy for testicular germ cell cancer.Semantic proximity Read ↗

Prevalence of HFE genotypes, C282Y and H63D, in patients with hematologic disorders.Semantic proximity Read ↗

Detecting the C282Y and H63D mutations of the HFE gene by Holliday Junction-based allele-specific genotyping methods.Semantic proximity Read ↗

Pulmonary Function in Patients With Germ Cell Cancer Treated With Bleomycin, Etoposide, and CisplatinSemantic proximity Read ↗

Clinical and genetic determinants of anthracycline-induced cardiac iron accumulation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.