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Article

HFE gene mutations in susceptibility to childhood leukemia: HuGE review.

Genetics in medicine : official journal of the American College of Medical Genetics - 1 Mar 2005

Dorak M Tevfik, Burnett Alan K, Worwood Mark

Abstract excerpt

The hereditary hemochromatosis (HHC) gene, HFE on chromosome 6p21.3, encodes a protein involved in iron homeostasis. HFE mutations have low penetrance with a mild effect on serum iron levels. Animal, twin, and population studies have shown that carrier state for C282Y can increase iron levels. A proportion of heterozygotes show slightly elevated serum iron levels. Increased serum iron has been suggested to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 15775751
DOI: 10.1097/01.gim.0000156532.04648.81

Genes

HFE
TFRC

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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