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Article

Impact of HFE variants and sex in lung cancer.

PloS one - 1 Jan 2019

Lee Sang Y, Walter Vonn, Zhu Junjia, Salzberg Anna C, Liu Dajiang J, Connor James R

Abstract excerpt

The homeostatic iron regulator protein HFE is involved in regulation of iron acquisition for cells. The prevalence of two common HFE gene variants (H63D, C282Y) has been studied in many cancer types; however, the impact of HFE variants, sex and HFE gene expression in lung cancer has not been studied. We determined the prevalence of HFE variants and their impact on cancer phenotypes in lung cancer cell lines, in...

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Identifiers

PMID: 31856248
DOI: 10.1371/journal.pone.0226821
PMCID: PMC6922424

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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