Article
Genetic variation in the bleomycin hydrolase gene and bleomycin-induced pulmonary toxicity in germ cell cancer patients.
Pharmacogenetics and genomics - 1 Jun 2005
Nuver Janine, Lutke Holzik Martijn F, van Zweeden Martine, Hoekstra Harald J, Meijer Coby, Suurmeijer Albert J H, Groen Harry J M, Hofstra Robert M, Sluiter Wim J, Groen Henk, Sleijfer Dirk T, Gietema Jourik A
Abstract excerpt
OBJECTIVE: Use of bleomycin as a cytotoxic agent is limited by its pulmonary toxicity. Bleomycin is mainly excreted by the kidneys, but can also be inactivated by bleomycin hydrolase (BMH). An 1450A>G polymorphic site in the BMH gene results in an amino acid substitution in the C-terminal domain of the protein. Deletion of this domain, including the polymorphic site, reduces enzymatic activity. We investigated...
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