Article
Variation in bleomycin hydrolase gene is associated with reduced survival after chemotherapy for testicular germ cell cancer.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 10 Apr 2008
de Haas Esther C, Zwart Nynke, Meijer Coby, Nuver Janine, Boezen H Marike, Suurmeijer Albert J H, Hoekstra Harald J, van der Steege Gerrit, Sleijfer Dirk Th, Gietema Jourik A
Abstract excerpt
PURPOSE: Response to chemotherapy may be determined by gene polymorphisms involved in metabolism of cytotoxic drugs. A plausible candidate is the gene for bleomycin hydrolase (BLMH), an enzyme that inactivates bleomycin, an essential component of chemotherapy regimens for disseminated testicular germ-cell cancer (TC). We investigated whether the single nucleotide polymorphism (SNP) A1450G of the BLMH gene...
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